Acetone HPLC 2.5L

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Acetone HPLC – Identification of Product
Chemical Code: HPLC-A1
Chemical Name: Acetone
Chemical Grade: HPLC
Chemical Formula: CH₃COCH₃
Chemical Weight: 58.08 g/mol
CAS No: 67-64-1
Chemical Synonyms: 2-Propanone, di-Methyl Ketone, Propan-2-one, Dimethyl Ketone.

Acetone HPLC – Hazards Identification
REACH No: 01-2119471330-49-XXXX
Signal Word: Danger
Supplemental Hazard Information: Repeated exposure may cause skin dryness or cracking
Additional Hazard Information: This substance contains no components considered to be either persistent, bio-accumulative and toxic (PBT), or very persistent and very bio-accumulative (vPvB) at levels of 0.1% or higher.

Acetone HPLC – Hazards statements
H225 – Highly flammable liquid and vapour.
H319 – Causes serious eye irritation.
H336 – May cause drowsiness or dizziness.
Precautionary statements
P210 – Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P280 – Wear eye protection/face protection.
P304 + P340 + P312 – If inhaled: Remove person to fresh air and keep comfortable for breathing. Call a Poison center/doctor if you feel unwell.
P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337 + P313 – If eye irritation persists: Get medical advice/attention.
P403 + P235 – Store in a well-ventilated place. Keep cool.

Acetone HPLC – Composition of Chemical
Chemical Formula: CH₃COCH₃
EC No 1272/2008: 01-2119471330-49-XXXX

Acetone HPLC – First Aid Measures
General Advice: Consult a physician. Show this safety data sheet to the doctor in attendance.
If: Inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
If: Skin Contact: Wash off with soap and plenty of water. Consult a physician.
If: Eye Contac: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If: Swallowed: Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Important Symptoms: The most important known symptoms and effects are described in the labelling section.
Immediate Medical Attention: No Data Available
Firefighting MeasuresExtinguishing Media: Use Water spray, Alcohol-resistant foam, Dry chemical or Carbon Dioxide.
Hazards Arising: No Data Available
Advice for Firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
Info for Firefighting: Use water spray to cool unopened containers.

Acetone HPLC – Accidental Release Measures
Personal Precautions: Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Ensure adequate ventilation.
Remove all sources of ignition.
Evacuate personnel to safe areas.
Beware of vapours accumulating to form explosive concentrations.
Vapours can accumulate in low areas.
Enviromental Precautions: Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Method for Containment: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

Acetone HPLC – Handling and Storage
Personal Precautions: Avoid contact with skin and eyes.
Avoid inhalation of vapour or mist.
Keep away from sources of ignition – No smoking.
Take measures to prevent the build up of electrostatic charge.
Enviromental Precautions: Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Exposure Controls | Personal Protection
Derived No Effect Level (DNEL)
Workers | Application Area | Exposure Routes | Health Effect | Value
Workers – Skin contact – Long-term systemic effects – 186mg/kg BW/d
Workers – Inhalation – Acute systemic effects – 2420 mg/m³
Workers – Inhalation – Long-term systemic effects – 1210 mg/m³
Consumers | Application Area | Exposure Routes | Health Effect | Value
Consumers – Ingestion – Long-term systemic effects – 62mg/kg BW/d
Consumers – Skin contact – Long-term systemic effects – 62mg/kg BW/d Consumers – Inhalation – Long-term systemic effects – 200 mg/m³
Predicted No Effect Concentration (PNEC)
Soil – 33.3 mg/Kg
Marine water – 1.06 mg/L
Fresh water – 10.6 mg/L
Marine sediment – 3.04 mg/Kg
Fresh water sediment – 30.4 mg/Kg
Onsite sewage treatment plant – 100 mg/L
Engineering Controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Eye/Face Protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU).
Skin Protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Full contact
Material: butyl-rubber. Minimum layer thickness: 0,3 mm
Break through time: 480 min. Material tested: Butoject®
Splash contact
Material: butyl-rubber. Minimum layer thickness: 0,3 mm
Break through time: 480 min. Material tested: Butoject®
Data source: KCL GmbH, D-36124, Test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Body Protection: Impervious clothing. Flame retardant anti-static protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory Protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator with multi-purpose combination, type OV/AG (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Physical and Chemical Properties
Appearance: Clear, Colourless, volatile liquid
Odour: No Data Available
Odour Threshold: No Data AvailablepH: No Data Available
Melting Point: Melting point/range: – 94°C
Boiling Point: 56°C at 1.013 hPa
Flash Point: – 17.0°C (closed cup).
Evaporation: No Data Available
Flammability: No Data Available
Upper/Lower Flammability or Explosive Limits: Upper explosion limit: 13% (V),
Lower explosion limit: 2% (V).
Vapour pressure: 533.3 hPa at 39.5°C,
245.3 hPa at 20.0°C.
Vapour density: No Data Available
Relative density: 0.791 g/mL at 25°C
Water solubility: Completely miscible
Partition Coefficien: Log Pow: – 0.24
Auto-ignition Temperature: 465.0°C
Decomposition Temperature: No Data Available
Viscosity: No Data Available
Explosive properties: No Data Available
Oxidizing properties: No Data Available
Other Safety Info: Surface tension: 23.2 mN/m at 20.0°C

Stability and Reactivity
Reactivity: No Data Available
Chemical Stability: Stable under recommended storage conditions.
Possibility of hazardous reactions: No Data Available
Conditions to Avoid: Heat, flames and sparks
Incompatible Materials: Bases, Oxidizing agents, Reducing agents.
Acetone reacts violently with Phosphorous Oxychloride.
Hazardous Decomposition Products: Hazardous decomposition products formed under fire conditions – Carbon Oxides.

Toxicological Information
Acute Toxicity: LD50 Oral – Rat – 5.800 mg/kg
Remarks: Behavioral: Altered sleep time (including change in righting reflex)Behavioral: Tremor
Behavioral: Headache
Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhoea
LC50 Inhalation – Rat – 8 h – 50.100 mg/m³
Remarks: Drowsiness, Dizziness, Unconsciousness
LD50 Dermal – Guinea pig – 7.426 mg/kg
Skin Corrosion/Irritation: Rabbit –
Result: Mild skin irritation – 24 h
Serious Eye damage | Eye Irritation: Rabbit –
Result: Eye irritation – 24 h
Cell Mutagenicity: No Data Available
Carcinogenicity: This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification.
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity: No Data Available
Specific Target Organ Toxicity – Single Exposure: May cause drowsiness or dizziness.
Specific Target Organ Toxicity – Repeated Exposure: No Data Available
Aspiration Hazard: No Data Available

Ecological Information
Ecological Toxicity: Toxicity to fish:
LC50 – Oncorhynchus mykiss (rainbow trout) – 5.540 mg/l – 96 h.
Toxicity to daphnia and other aquatic invertebrates:
LC50 – Daphnia magna (Water flea) – 8.800 mg/l – 48 h.
Ecological Persistence and degradability: Biodegradability:
Result: 91% – Readily biodegradable (OECD Test Guideline 301B)
Bioaccumulative Potential: Does not bio-accumulate
Mobility in Soil: No Data Available
Results of PBT and vPvB Assessment: This substance contains no components considered to be either persistent, bio-accumulative and toxic (PBT), or very persistent and very bio-accumulative (vPvB) at levels of 0.1% or higher.
Other Adverse Effect: No Data Available
Disposal ConsiderationsWaste Treatment Methods: Product –
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging – Dispose of as unused product.

Transport Information
UN Number: ADR/RID: 1090
IMDG: 1090
IATA: 1090
UN Shipping Hazard: ADR/RID: ACETONE
IATA: Acetone
Transport Hazard Class: ADR/RID: 3
Packaging Group: ADR/RID: II
Enviromental Hazards: ADR/RID: no
IMDG Marine pollutant: no
IATA: no
Special Precautions: No Data Available
Regulatory Information
Safety, Health and environmental regulations: This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Chemical Safety Assessment: A Chemical Safety Assessment has been carried out for this substance.
Additional Info: RTECS: AL3150000.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Kidney – Irregularities – Based on Human Evidence
Skin – Dermatitis – Based on Human Evidence

The information stated above is considered to be correct, but does not claim to be inclusive and shall only be used as a guideline. The information provided by this document is confirmed by our continuous updating of knowledge and adheres to the products appropriate safety precautions. It does not represent any guarantee of the product’s
properties. RLS Chemicals and its Associates shall not be held accountable for any damage’s consequent of handling the above product

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