Tetrahydrofuran HPLC – Identification of Product
Chemical Code: HPLC-T1
Chemical Name: Tetrahydrofuran
Chemical Grade: HPLC
Chemical Formula: C₄H₈O
Chemical Weight: 72,11 g/mol
CAS No: 109-99-9
Chemical Synonyms:
Tetrahydrofuran HPLC – Hazards Identification
REACH No: 01-2119444314-46-XXXX
Signal Word: Danger
Supplemental Hazard Information: EUH019 – May form explosive peroxides.
Additional Hazard Information: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Hazards statementsH225 – Highly flammable liquid and vapour.
H302 – Harmful if swallowed.
H319 – Causes serious eye irritation.
H335 – May cause respiratory irritation.
H351 – Suspected of causing cancer.
Tetrahydrofuran HPLC – Precautionary statements
P210 – Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P280 – Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P312 + P330 – IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P305 + P351 + P338 – IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P370 + P378 – In case of fire: Use dry powder or dry sand to extinguish.
P403 + P235 – Store in a well-ventilated place. Keep cool.
Tetrahydrofuran HPLC – Composition of Chemical
Chemical Formula: C₄H₈O
EC No 1272/2008: 01-2119444314-46-XXXX
Tetrahydrofuran HPLC – First Aid Measures
General Advice: Consult a physician. Show this safety data sheet to the doctor in attendance.
If: Inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
If: Skin Contact: Wash off with soap and plenty of water. Consult a physician.
If: Eye Contac: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If: Swallowed: Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Important Symptoms: No Data Available
Immediate Medical Attention: No Data Available
Tetrahydrofuran HPLC – Firefighting Measures
Extinguishing Media: Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.
Hazards Arising: No Data Available
Advice for Firefighters: Wear self-contained breathing apparatus for firefighting if necessary.Info for Firefighting: Use water spray to cool unopened containers.
Accidental Release Measures
Personal Precautions: No Data Available
Enviromental Precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Method for Containment: Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local / national regulations.
Handling and Storage
Personal Precautions: Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition – No smoking. Take measures to prevent the build up of electrostatic charge.
Enviromental Precautions: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store in cool place. Dry residue is explosive. Store under inert gas. Test for peroxide formation periodically and before distillation.
Exposure Controls | Personal Protection
Derived No Effect Level (DNEL)
Workers | Application Area | Exposure Routes | Health Effect | Value
Workers – Skin contact – Long-term systemic effects – 25mg/kg BW/d
Workers – Inhalation – Long-term local effects 150 – mg/m3
Workers – Inhalation – Long-term systemic effects – 150 mg/m3
Consumers | Application Area | Exposure Routes | Health Effect | Value
Consumers – Skin contact Long-term systemic effects – 15mg/kg BW/d
Consumers – Inhalation Long-term systemic effects – 62 mg/m3
Consumers – Inhalation Acute local effects – 150 mg/m3
Consumers – Inhalation Acute systemic effects – 150 mg/m3
Predicted No Effect Concentration (PNEC)
Soil – 2,13 mg/kg
Marine water – 0,432 mg/l
Fresh water – 4,32 mg/l
Marine sediment – 2,33 mg/kg
Fresh water sediment – 23,3 mg/kg
Onsite sewage treatment plant -0 4,6 mg/l
Engineering Controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Eye/Face Protection: Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin Protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove’s outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,5 mm
Break through time: 12 min
Material tested:Camatril® (KCL 733 / Size M)
data source: KCL GmbH, D-36124test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Body Protection: Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory Protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Physical and Chemical Properties
Appearance: Colourless, clear liquid
Odour: Ether-like
Odour Threshold: No Data Available
pH: ca.7
Melting Point: Melting point/range: -108,44 °C at 1.013,25 hPa
Boiling Point: 65,0 – 67,0 °C at 1.013,25 hPa
Flash Point: -17,0 °C – closed cup
Evaporation: No Data Available
Flammability: No Data Available
Upper/Lower Flammability or Explosive Limits: Upper explosion limit: 11,8 %(V) Lower explosion limit: 1,8 %(V)
Vapour pressure: 170 hPa at 20,0 °CVapour density: ca.2,5 at 25 °C – (Air = 1.0)
Relative density: 0,89 g/cm3
Water solubility: soluble
Partition Coefficien: log Pow: 0,46
Auto-ignition Temperature: 215 °C at 1.013 hPa
Decomposition Temperature: No Data Available
Viscosity: 0,518 mm2/s at 25 °C – 0,403 mm2/s at 50 °C –
Explosive properties: Not explosive, In use may form flammable/explosive vapour-air mixture.
Oxidizing properties: The substance or mixture is not classified as oxidizing.
Other Safety Info: No Data Available
Stability and Reactivity
Reactivity: ca.2,5 at 25 °C – (Air = 1.0)
Chemical Stability: Stable under recommended storage conditions.
Possibility of hazardous reactions: No Data Available
Conditions to Avoid: Heat, flames and sparks.
Incompatible Materials: Strong oxidizing agents, Acids
Hazardous Decomposition Products: Hazardous decomposition products formed under fire conditions. – Carbon oxides
Toxicological Information
Acute Toxicity: LD50 Oral – Rat – male and female – 1.650 mg/kg
LC50 Inhalation – Rat – 6 h – 14,7 mg/l. Remarks: Material may be irritating to mucous membranes and upper respiratory tract.
LD50 Dermal – Rat – > 2.000 mg/kg
Skin Corrosion/Irritation: Based on available data, the classification criteria are not met.
Serious Eye damage | Eye Irritation: Eyes – Rabbit
Result: Risk of serious damage to eyes. (Draize Test)
Cell Mutagenicity: In vivo tests did not show mutagenic effects Ames test S. typhimurium
Result: negative
Carcinogenicity: IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.Reproductive toxicity: No toxicity to reproduction.
Specific Target Organ Toxicity – Single Exposure: May cause drowsiness or dizziness. – Nervous system
May cause respiratory irritation.
Specific Target Organ Toxicity – Repeated Exposure: The substance or mixture is not classified as specific target organ toxicant, repeated exposure.
Aspiration Hazard: No aspiration toxicity classification
Ecological Information
Ecological Toxicity: Toxicity to fish – LC50 – Pimephales promelas (fathead minnow) – 2.160 mg/l – 96 h
Toxicity to daphnia and other aquatic invertebrates_ EC50 – Daphnia magna (Water flea) – 382 mg/l – 24 h
Toxicity to algae – Growth inhibition IC50 – Algae – 3.700 mg/l – 192 h
Ecological Persistence and degradability: Biodegradability – (OECD Test Guideline 301)
Remarks: According to the results of tests of biodegradability this product is not readily biodegradable.
Bioaccumulative Potential: No bioaccumulation is to be expected (log Pow <= 4).
Mobility in Soil: No Data Available
Results of PBT and vPvB Assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other Adverse Effect: No Data Available
Disposal Considerations
Waste Treatment Methods: Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material must be
disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.
Contaminated packaging
Dispose of as unused product.
Transport Information
UN Number: ADR/RID: 2056
IMDG: 2056
IATA: 2056
UN Shipping Hazard: ADR/RID: TETRAHYDROFURAN
IMDG: TETRAHYDROFURAN
IATA: Tetrahydrofuran
Transport Hazard Class: ADR/RID: 3
IMDG: 3 IATA: 3
Packaging Group: ADR/RID: II
IMDG: II
IATA: II
Enviromental Hazards: ADR/RID: no
IMDG Marine pollutant: no
IATA: no
Special Precautions: No Data Available
Regulatory Information
Safety, Health and environmental regulations: This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Chemical Safety Assessment: A Chemical Safety Assessment has been carried out for this substance.
Additional Info: RTECS: LU5950000
Central nervous system depression, Cough, chest pain, Difficulty in breathing, Exposure to high airborne concentrations can cause anesthetic effects.
Disclaimer
The information stated above is considered to be correct, but does not claim to be inclusive and shall only be used as a guideline. The information provided by this document is confirmed by our continuous updating of knowledge and adheres to the products appropriate safety precautions. It does not represent any guarantee of the product’s
properties. RLS Chemicals and its Associates shall not be held accountable for any damage’s consequent of handling the above product
